They had a "particular system to look at the impact of all these drugs on the developing fetus to see were there any indicators of risk," he said, using rat fetuses.
The study "found that Paxil, of all the SSRIs on the market now, was the most likely to cause birth defects and caused birth defects at the same rate as Accutane did," Healy said.
He was asked how Paxil did in the study compared to cocaine in terms of potency.
"It was much more likely to cause birth defects than cocaine," he said. "Cocaine in this particular system was much safer than Paxil."
On September 21, 2009, the jury also heard testimony on the Sloot study from Doctor Shira Kramer, an epidemiologist. "Doctor Sloot's paper demonstrated that Paxil was a clear teratogen," she said, "that it was not just an effect of developmental or birth-weight related effect, that it was a direct teratogen, and that there was a spectrum of defects observed in rat embryos at low doses, establishing that it was a very potent teratogen, more teratogenic than cocaine and retinol, clear teratogens in their own right."
Parisian told the jury that the Sloot study, conducted in 2009, could have been conducted in 1981 and it would have answered the question that Dr Baldwin was asking about embryotoxicity in 1980.
"If you use that type of a study, it specifically addresses embryotoxicity," she told the jury.
Paxil Journey to Japan
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