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This measles-based vaccine candidate has been described as "a modified [genetically altered] measles virus that delivers bits of the new coronavirus into the body to prevent Covid-19" as well as an "attenuated [genetically modified yet weakened] measles virus as a vector with which to introduce genetic material from SARS-[CoV-]2 to the immune system." The combination of this weakened measles virus and SARS-CoV-2, per Duprex, will produce a "more benign version of coronavirus [that] will acquaint a person's immune system" with SARS-CoV-2. No vaccine using this modality has ever been licensed.
On April 2nd, less than a week after the CEPI award had been announced, the UPMC researchers who had developed the original vaccine candidate using the more traditional adenovirus-vector approach published a study in EBioMedicine (a publication of the medical journal Lancet) that reported promising results of their vaccine candidate in animal studies. The news that a US institution was among the first in the world to develop a Covid-19 vaccine candidate with promising results from an animal study was heavily amplified by mainstream US media outlets, with those reports noting that UMPC was requesting government permission to quickly move onto human trials.
This original vaccine candidate, however, was mysteriously dropped from subsequent reports and statements from UPMC regarding its Covid-19 vaccine efforts. Indeed, in recent months, Duprex's statements on the center's Covid-19 vaccine candidates no longer mention the once-promising PittCoVacc at all. Instead, new reports, citing Duprex, claim that the only UPMC vaccine candidates are the CEPI-funded measles-vaccine candidate and another, more mysterious vaccine candidate, whose nature has only been recently revealed by documents obtained through a Freedom of Information Act (FOIA) request.
Equally odd is that recent media reports on the original vaccine candidate have stopped mentioning UPMC at all, instead citing only Themis, its new owner Merck, and France's Institut Pasteur. There are no reports indicating a break-up of the original "academic-industry partnership" that had received the CEPI grant. It seems that this is what may have come to pass, as Duprex stated that the UPMC measles-vector vaccine candidate had partnered with the Serum Institute of India for mass production, first for trials and then for public use, depending on how the vaccine advances through the regulatory process. In contrast, Themis/Merck have stated that their vaccine is being produced in France. It remains unclear what the relation is between these two, and apparently analogous, vaccine candidates.
Though Duprex has been relatively forthcoming about the nature of the first UPMC vaccine candidate (i. e., the CEPI-funded measles-vector vaccine), he has been much more tight-lipped about its second vaccine candidate. In late August, he told the Pittsburgh Business Times that the second vaccine candidate that UPMC was developing "works by delivering genetic material coding for a viral protein instead of the entire weakened or killed virus as is standard in other vaccines." Yet Duprex declined to state what vector will be used to deliver the genetic material into human cells. Recent FOIA revelations, nevertheless, have revealed that UPMC's second vaccine candidate involves genetically engineering a combination of SARS-Cov-2 and anthrax, a substance better known for its potential use as a bioweapon.
Corona-thraxThe recently obtained documents reveal that the BSL-3 lab that is part of UPMC's Center for Vaccine Research is conducting eyebrow-raising research involving combining SARS-CoV-2 with Bacillus anthracis, the causative agent of anthrax infection. Per the documents, anthrax is being genetically engineered by a researcher, whose name was redacted in the release, so that it will express the SARS-CoV-2 spike protein, which is the part of the coronavirus that allows it to gain access into human cells. The researcher asserts that "the [genetically engineered anthrax/SARS-CoV-2 hybrid] can [be] used as a host strain to make SARS-CoV-2 recombinant S protein vaccine," and the creation of said vaccine is the officially stated purpose of the research project. The documents were produced by the University of Pittsburgh's Institutional Biosafety Committee (IBC), which held an emergency meeting on June 22nd of this year to "discuss specific protocols involving research with the coronavirus," which included a vote on the aforementioned proposal.
Edward Hammond, the former director of the Sunshine Project, an organization that opposed chemical and biological weapons and the expansion of "dual use" biodefense/bioweapon research, obtained the documents. Other FOIA documents recently obtained by Hammond have revealed an "explosion" of risky Covid-19-related research at other academic institutions, such as the University of North Carolina, which has already had lab accidents involving genetically engineered variants of SARS-CoV-2.
Hammond told The Last American Vagabond that the experiment, which he dubs "Corona-thrax," is "emblematic of the pointless research excesses that often characterize the response of scientists to the federal government throwing billions of dollars at health crises." Hammond added, "While I don't think that Corona-thrax would be infectious, it falls into the categories of pointless and crazy. The biggest immediate risk of all this activity is that a researcher will deliberately or inadvertently create a modified form of SARS-CoV-2 that is even more difficult to treat, or more deadly, and this virus will escape the lab. It only takes a stray droplet."
Jonathan Latham, a virologist who previously taught at the University of Wisconsin and who is the current editor of Independent Science News, agreed with Hammond that the Corona-thrax experiment is odd and said that he was "concerned here specifically about the research process and the risks of these specific experiments at Pittsburgh." In an interview with The Last American Vagabond, Latham asserted that it is "unusual by historical standards . . . the combining of two highly pathogenic organisms in a single experiment." He did note, however, that such studies for the purposes of vaccine research have become more common in recent years, as is made clear in a 2012 study.
Few experiments have been conducted that specifically utilize anthrax in this way. Since 2000, the studies that have examined the use of genetically modified anthrax as a potential vaccine vector have been affiliated with Harvard University. One of these studies was on the use of anthrax as a vector in a potential HIV vaccine and was jointly conducted in 2000 by Harvard researchers and the vaccine company Avant Immunotherapeutics (now part of Celldex).
Despite reporting positive preliminary results in their experiments, Avant/Celldex did not fund further experiments into a vaccine that used this anthrax-based modality, and it does not currently market or have any such vaccine in its product pipeline. This suggests that, for whatever reason, this company did not see much value in this vaccine, despite the preliminary study with Harvard claiming that the methodology was safe and effective.
The Harvard researchers involved in that 2000 study, however, continued to investigate the possibility of an anthrax-based HIV vaccine in 2003, 2004, and 2005, though without corporate sponsorship. Related yet different research has explored the use of "disarmed" anthrax components as an adjuvant in vaccines and as the basis for enzyme-linked immunospot assays.
The aforementioned Harvard researchers patented their methodology of using anthrax in this way for the production of a vaccine in 2002. This means that the anthrax-based "vaccine" currently being developed by UPMC's Center for Vaccine Research would have to develop a new method that utilizes anthrax in much the same way so as not to infringe on the patent, which is unlikely. The other alternative is that UPMC would pay the patent holders for use of their methodology if they want to commercialize it in a vaccine. Yet, given UPMC's business model in general, as well as that of UPMC's Center for Vaccine Research specifically, this also seems unlikely.
Also odd is what sort of incentive UPMC's Center for Vaccine Research possesses for the Corona-thrax experiment. There are currently over a hundred vaccine candidates that use existing and tested vaccine platforms in pursuit of a Covid-19 vaccine, a fact Duprex himself has acknowledged. As Hammond told The Last American Vagabond, "It is perfectly obvious that there are numerous existing vaccine platforms for Covid-19 and that some of them will, sooner or more likely later, succeed. There is no serious need for some sort of quite strange bacterial platform, much less one that happens to be anthrax. It's completely unnecessary and frankly bizarre."
The Crown Jewel of the Biotech-Industrial ComplexThe Corona-thrax experiment is being conducted at the Center for Vaccine Research's Regional Biocontainment Laboratory (RBL), where the center's work with pathogenic agents, such as anthrax and SARS-CoV-2, is conducted.
The creation of UPMC's RBL was first announced in 2003, when the National Institute of Allergy and Infectious Diseases (NIAID, then and currently led by Anthony Fauci) stated it would fund the laboratory's construction with an $18 million grant. It was originally planned to be mainly "dedicated to research on agents that cause naturally occurring and emerging infections, as well as potential agents of bioterrorism." The plan to create the lab was part of the US government decision to dramatically ramp up "biodefense" research in the wake of the 2001 anthrax attacks.
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