- BPaLC arm; and
- BPaL arm.
As of now, BPaLM regimen has been found to be non-inferior to the standard of care (9-24 months) treatment of rifampicin-resistant TB of the lungs. Outcomes of other regimens are expected to be reported soon, shared Dr Moore who is also a member of the TB PRACTECAL Trial Steering Committee.
TB Preventive Treatment (TPT) for MDR-TB
A person with latent TB (or latent drug-resistant TB) infection does not have symptoms and cannot spread TB bacteria to others. But in some of them the latent TB infection will progress to active TB disease in their life. All cases of active TB come from this pool of people with latent TB infection. That is why it is important to correctly diagnose those with latent TB infection and provide TB preventive treatment to them so that their risk of progressing to active TB disease is decimated.
Many ongoing studies are evaluating 6-months MDR-TB preventive therapies for close contacts of MDR-TB patients:
TB CHAMP study is examining Levofloxacin as MDR-TB preventive therapy in children under the age of 5 years who are close contacts of adults diagnosed with MDR-TB.
PHOENix (Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients) is a multi-country study comparing Delamanid with Isoniazid for preventing MDR-TB in children, adolescents and adults who are close contacts of persons with MDR-TB.
V-QUIN study in Vietnam is examining the efficacy of Levofloxacin for treating latent MDR-TB in all household contacts of patients with bacteriologically-confirmed Rifampicin-resistant TB.
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