Power of Story
Send a Tweet        
- Advertisement -
Exclusive to OpEdNews:
Sci Tech

The Origin of Bioidentical Hormones

By   Follow Me on Twitter     Message Jeffrey Dach     Permalink
      (Page 1 of 2 pages)
Related Topic(s): ; ; , Add Tags Add to My Group(s)

View Ratings | Rate It

opednews.com Headlined to H4 6/24/13

Author 30652
Become a Fan
  (13 fans)
- Advertisement -


Dioscorea mexicana, Mexican yam, barbasco de placa
(Image by Wikimedia commons)
  Permission   Details   DMCA

Dioscorea mexicana, Mexican yam, barbasco de placa by Wikimedia commons
Russell Marker and the Origin of Bioidentical Hormones

by Jeffrey Dach MD   Link to original article

Where do Hormones Come From ?

- Advertisement -

A couple of times a week, I get the question, "Where do hormones comes from?"  They were originated by Russell E Marker, a chemist who made progesterone from the plant steroid called Diosgenin.

Who was Russell Marker ?

Russell Marker was a Penn State chemist in 1938 who invented a practical way to mass produce progesterone, a bioidentical hormone. using a technique known as the Marker degradation process.

- Advertisement -

In 1938, Marker was a chemistry professor at Pennsylvania State College. While working on plant-steroid chemistry, Marker found a plant steroid from the Dioscorea family called Diosgenin, which could be easily converted into the bioidentical hormone, progesterone.  Next, Marker needed an economical source of the plant material to isolate the plant steroid called Diosgenin.

Finding the Plant Material in Mexico

In November 1941, Marker found what he had been searching for in a botany textbook describing a Dioscorea plant indigenous to Veracruz in Mexico, called Cabeza de Negro.

In 1942, Marker then traveled to Mexico, where he purchased some of the Dioscorea plant material and started the mass production of Progesterone.

In 1943, Marker resigned from Penn State University and moved to Mexico to begin mass production of progesterone and other bioidentical hormones.   Marker refused to assign patent rights to anyone, granting free and open use of his invention to the general public.

In early 1944, Syntex was formed in Mexico to manufacture progesterone from Diosgenin.  In May 1945, Marker left Syntex and started a new company, Botanica-mex, near Mexico City, which then made several kilograms of progesterone.   Botanica-mex folded in March 1946 and was restarted as a new company called HormonoSynth.   During this time, the cabeza de negro plant source for Diosgenin was replaced by the barbasco plant, containing 500% more Diosgenin.   After Marker's retirement, the company was again reorganized as Diosynth.

- Advertisement -
Syntex After Marker Leaves  -- Syntex Prospers

After Marker left Syntex in October 1945, the company recruited a replacement chemist, George Rosenkranz, and Syntex was again selling progesterone.   In addition to extending the chemical process to the production of testosterone and other bioidentical hormones,  Rosenkranz also built a research program at Syntex, and recruited other Ph.D. chemists including Carl Djerassi and Alejandro Zaffaroni.

Cortisone and the "Pill"   

Further research at Syntex led to discovery that this same p lant-steroid precusor Diosgenin could be converted to cortisone, a powerful anti-inflammatory steroid.  They also worked on the first synthetic birth-control pills.   By the 1950s, Syntex and its competitors were the major supplier of sex hormones to the United States.

Health Benefits of Diosgenin

Next Page  1  |  2

 

- Advertisement -

View Ratings | Rate It

http://jeffreydachmd.com
Jeffrey Dach MD is a physician and author of two books, Natural Medicine 101, and Bioidentical Hormones 101, both available on Amazon, or as a free e-book on his web sites. Dr. Dach is founder and chief medical officer of TrueMedMD, a clinic in (more...)
 

Share on Google Plus Submit to Twitter Add this Page to Facebook! Share on LinkedIn Pin It! Add this Page to Fark! Submit to Reddit Submit to Stumble Upon



Go To Commenting
/* The Petition Site */
Series: "Bioidentical Hormones"

View All 1 Articles in "Bioidentical Hormones"
Total Views for the Series: 1001   

The views expressed in this article are the sole responsibility of the author and do not necessarily reflect those of this website or its editors.

Follow Me on Twitter

Contact AuthorContact Author Contact EditorContact Editor Author PageView Authors' Articles
- Advertisement -

Most Popular Articles by this Author:     (View All Most Popular Articles by this Author)

Failed Hatchet Job on Larry King, Suzanne Somers, Knockout

Bioidentical Hormones on Oprah, Are They Safe?

Why Natural Thyroid is Better than Synthetic

Wheatgrass, Natural Medicine in the Kitchen

Fish Oil Increases Risk for Prostate Cancer, New Study?

Spontaneous Remission Cancer Breakthrough