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More Misinformation on Bioidentical Hormones

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Jeffrey Dach
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Links and references

1) http://www.cbsnews.com/news/bioidenticals-no-safer-than-other-hormone-replacement-therapy/   By Michelle Castillo CBS News October 29, 2013, 7: 16 AM Bioidenticals no safer than other hormone replacement therapy

2) http://www.ncbi.nlm.nih.gov/pubmed/10468650 
Altern Med Rev. 1999 Aug;4(4):266-70. Comparative measurements of serum estriol, estradiol, and estrone in non-pregnant, premenopausal women; a preliminary investigation. Wright JV, Schliesman B, Robinson L.  Source  Tahoma Clinic, 515 W. Harrison, Ste. 200, Kent, WA 98031, USA.

The fractionated estrogen concentration data from the population of 26 women
shows that the estriol in every case was at least three times as great as the concentration of estradiol and estrone combined. With estriol circulating at nearly 10 times the concentration of estrone and estradiol, it appears at least a possibility that there must be unknown significant biological activity for this "weaker"
hormone.

3)http://www.ncbi.nlm.nih.gov/pubmed/10714912  Maturitas. 2000 Feb 15;34(2):169-77. Efficacy and safety of oral estriol for managing postmenopausal symptoms. Takahashi K, Manabe A, Okada M, Kurioka H, Kanasaki H, Miyazaki K.
Source Department of Obstetrics and Gynecology, Shimane Medical University, Izumo, Japan.

to assess the therapeutic efficacy and safety of oral estriol for the treatment of climacteric symptoms in postmenopausal women.
METHODS:  68 postmenopausal women with climacteric symptoms received oral estriol, 2 mg/day, daily for 12 months. We evaluated the degree of climacteric complaints with estriol therapy; serum levels of gonadotropins, estradiol (E2) and lipids; biochemical markers of bone metabolism; blood pressure; and side effects both at baseline and during treatment. Climacteric symptoms were assessed according to the menopausal index (MI), a version of the Kupperman index that had been modified for Japanese women.
RESULTS:  oral estriol therapy significantly reduced total MI scores. The greatest relief was noted for hot flushes, night sweats, and insomnia. Estriol treatment significantly lowered serum follicle stimulating hormone (FSH) and luteinizing hormone (LH) concentrations but did not affect any of the other parameters (lipids, bone, liver and blood pressure) during the study period. Slightly vaginal bleeding occurred in 14.3% of those who underwent natural menopausal women. Histologic evaluation of the endometrium and ultrasound assessment of the breasts following 12 months of estriol treatment found normal results in all women.
CONCLUSION:  Estriol is a safe and effective alternative for relieving climacteric symptoms in postmenopausal Japanese women.

4) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760629/

Estrogen Treatment in Multiple Sclerosis -- Stefan M Gold and Rhonda R Voskuhl*
Multiple Sclerosis Program, Department of Neurology, and Cousins Center, Geffen School of Medicine, University of California Los Angeles, U.S.A.
*Corresponding author, Address: Neurosci Res Bldg 1, 4th Floor, 635 Charles E Young Dr S, Los Angeles, CA 90095, U.S.A

Quantitatively, estriol is a very weak estrogen and preferentially binds ERß versus ERa (61--64). This is important since binding of each ER can result in opposite effects on transcription (65). Estriol has been accepted as the safest of the three estrogens in reviews dating from the 1970s to the 2000s (66--69). It has been used extensively in Europe and Asia for the treatment of menopausal symptoms (70--77) and, unlike 17ß-estradiol, causes minimal uterine endometrial proliferation (69, 70, 77--80). Further, treatment with estriol of 911 women with climacteric complaints in a five-year prospective study was not associated with endometrial or ovarian cancer (80).

5) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127562/
Mayo Clin Proc. 2011 July; 86(7): 673--680.
Bioidentical Hormone Therapy -- Julia A. Files, MD, Marcia G. Ko, MD, and Sandhya Pruthi, MD  From the Division of Women's Health Internal Medicine (J.A.F., M.G.K.), Mayo Clinic, Scottsdale, AZ; and Division of General Internal Medicine (S.P.), Mayo Clinic, Rochester, MN.

The claim that the safety profile of bioidentical compounds is better than that of FDA-approved HT15 belies the complexities of the topic. Both CBHT and FDA-approved HT are available in various dosages, combinations, preparations, and routes of delivery that may have differing effects on risk to an individual patient.26

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Jeffrey Dach MD is a physician and author of three books, Natural Medicine 101, and Bioidentical Hormones 101, and Heart Book all available on Amazon, or as a free e-book on his web sites. Dr. Dach is founder and chief medical officer of (more...)
 

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