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How Pharma Got Doctors to Prescribe Risperdal, Wellbutrin, Bextra, Neurontin, Prempro and More

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Until 2010 when the Physician Payments Sunshine Act which requires disclosure of Pharma payments passed, the only thing better than working for Pharma was being a doctor wined and dined by Pharma. Pfizer jetted 5,000 doctors to Caribbean resorts where they enjoyed massages, golf and $2,000 honoraria charges Blue Cross & Blue Shield to sell its painkiller Bextra ( withdrawn from the market in 2005 for heart risks). GSK sent doctors to lavish resorts to promote Wellbutrin, charges the Justice Department . Johnson & Johnson bestowed trips, perks and honoraria on Texas Medicaid officials to get its drug Risperdal preferred on the formulary, charged a state lawsuit. Bristol-Myers Squibb enticed doctors to prescribe its drugs with access to the Los Angeles Lakers and luxury box suites for their games, say California regulators . In China GSK is charged with using a network of 700 middlemen and travel agencies to bribe doctors with cash and sexual favors and Victory Pharma , an opioid drugs maker, was charged with treating doctors to strip shows. Nice.

 
Selling wonder drugs by Martha Rosenberg

Of course, Pharma reps did as well as the doctors. Thanks to their Barbie and Ken doll looks and the free samples, gifts and lunches they would bring medical staff, they would often waltz in to see the doctor before waiting and sick patients . Some had their own lounges at medical offices. Pharma reps were so famous for feeding their prescriber prospects, during a question and answer period at a medical conference about cutting financial ties to Pharma, a doctor asked in all earnestness, "but what will we do for lunch?"

The shameless schmoosing of Pharma reps even sparked jokes like these.

The Devil offered a Pharma rep $3 million a year if he would consign his wife and children's souls to hell. "What's the catch?" he asked.

A doctor was drinking at the bar and every few minutes took a picture out of his pocket and looked at it. "What are you doing?" asked the bartender. "I have my drug rep's picture in there," said the doc. "When he starts to look honest, I've had enough to drink."

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Trips to resorts and strip clubs will likely continue to diminish under the Physician Payments Sunshine Act but there are many other ways, often sneaky, that Pharma can entice doctors to prescribe its expensive, patent drugs.

Spying on Prescribing

Like the NSA spying program, shameless spying on doctors' prescribing habits spares almost no one. Recently, the full sweep of IMS Health Holdings' prescription data mining was revealed by ProPublica who reported that IMS' collection includes over 85 percent of the world's prescriptions and "comprehensive, anonymous medical records for 400 million patients." In 2007, there was a backlash against another seller of medical information: the AMA itself. By selling the names, office addresses and practice types of almost every doctor in the US to marketing firms the AMA netted almost $50 million a year the American Medical Student Association and the National Physicians Alliance charged at the AMA's convention . The database of 900,000 doctors does not violate privacy, counters the AMA, since doctors can opt out.

Psychiatrist Dan Carlat wrote in the New York Times that he was "astonished at the level of detail that drug companies were able to acquire about doctors' prescribing habits" and that his drug reps told him "they received printouts tracking local doctors' prescriptions every week." A 2011 Supreme Court ruling found the collection and dissemination of prescribing behavior was "speech" and protected by the First Amendment. (See: a corporation is a person")

CMEs

In order to keep their state licenses and satisfy insurance regulations, doctors must enroll in a certain amount of CMEs-- continuing medical education courses. Not surprisingly, these classes are often "taught" for free by Pharma funded specialists sparing doctors from having to pay for them but providing the objectivity of a time-share presentation. One such class, called "Atypical Antipsychotics in Major Depressive Disorder: When Current Treatments Are Not Enough," funded by Seroquel maker AstraZeneca was taught by former Emory University psychiatrist Charles Nemeroff, who lost his department chairmanship due to unreported Pharma income. Another CME   called "Bipolar Disorder: Individualizing Treatment to Improve Patient Outcomes," was "taught" by Trisha Suppes, who admits to funding by Abbott, AstraZeneca; GlaxoSmithKline, Janssen, Novartis, Pfizer, Wyeth, Bristol-Myers Squibb, Eli Lilly, Shire and four more Pharma companies. Another CME, "Individualizing ADHD Pharmacotherapy with Disruptive Behavioral Disorders" was taught by the Johnson & Johnson-funded Robert L. Findling and refers to Risperdal or its generic version, risperdone, 13 times. Many CMEs teach doctors about the lucrative new disease category of Adult ADHD and how to keep kids from going off their ADHD meds when they get to college. Ka-ching.

Ghostwriting

Being published in medical journals is essential to academic doctors but researching, writing and reworking papers is a formidable job. Luckily for doctors, Pharma is willing to help--as long as the doctors write what Pharma wants.   In just three years, medical writers associated with Parke-Davis, which became Pfizer, wrote 13 papers extolling the benefits of Neurontin, including in the prestigious Cleveland Clinic Journal of Medicine , in the names of the "author" doctors. Medical writers at Wyeth, also now Pfizer, wrote more than 50 papers pushing the now discredited Hormone Replacement Therapy (HRT) in the names of doctor "authors."

"Is There an Association Between Hormone Replacement Therapy and Breast Cancer?" asked one article in the Journal of Women's Health . Guess what it concludes? "The Role of Hormone Replacement Therapy in the Prevention of Postmenopausal Heart Disease," another ghostwritten paper, is titled, despite HRT's established heart risks, appearing in the Archives of Internal Medicine . And despite HRT's links to dementia, another paper, which also ran in the Archives of Internal Medicine, was titled "The Role of Hormone Therapy in the Prevention of Alzheimer's disease." Maybe there needs to be a new joke about the Pharma-funded papers. The Devil tells doctors they can contribute to medical journals if they're willing to write marketing messages instead of about medical research. "What's the catch?" some ask.

Clinical Trials

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Martha Rosenberg is an award-winning investigative public health reporter who covers the food, drug and gun industries. Her first book, Born With A Junk Food Deficiency: How Flaks, Quacks and Hacks Pimp The Public Health, is distributed by Random (more...)
 

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Many say blockbuster drugs have been replaced by b... by Martha Rosenberg on Monday, Feb 17, 2014 at 1:06:40 PM
You don't have high opinion about the doctors, do... by BFalcon on Tuesday, Feb 18, 2014 at 10:30:41 AM
Faux trials and ghost writing aren't only impactin... by Chris Robinett on Tuesday, Feb 18, 2014 at 3:27:34 PM
Thanks for shining the light on this.  What i... by Kevin Anthony Stoda on Tuesday, Feb 18, 2014 at 6:38:32 AM
Great article, thanks! ... by Meryl Ann Butler on Tuesday, Feb 18, 2014 at 7:08:19 AM
Thank you for all the research on this, Martha. ... by Cynthia Piano on Tuesday, Feb 18, 2014 at 8:13:52 AM
I was raised in the culture of the big-Pharmaceut... by Nancy Crouse on Tuesday, Feb 18, 2014 at 10:16:06 AM
For the first 37 years of my life, I was an undiag... by Eric Arthur Blair on Tuesday, Feb 18, 2014 at 10:39:27 AM
Once upon a time there was an HMO (Health Mainten... by Marilyn LaCourt on Tuesday, Feb 18, 2014 at 11:11:13 AM
Why would anyone ever go to a doctor for health p... by Ken Wertz on Tuesday, Feb 18, 2014 at 11:50:25 AM