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Review raises questions over aspartame and brain health

By staff reporter from Food Quality News.com  Posted by Stephen Fox (about the submitter)     Permalink
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[Contributors' Note: This new study is absolutely essential to comprehend, in the regrettable context of the stalled legislation in both the Hawaii House and Senate Committees. When the truth of this eventually dawns far into the future on officials like the Director of the Hawaii Department of Health, Dr. Chiyome Fukino, who relied totally on the discredited Toxicology magazine "study" which was totally paid for by Ajinomoto of Japan, all of the legislators who capitulated to her counsel and that of the grocers, soft drink bottlers, etc., will appear to have been tragically misinformed and entirely misled by corporate perfidy.

Request to Hawaii Legislators: please schedule SCR191 and HCR132 as soon as possible. They are both vital as efforts to protect the Health of Hawaiians, and their fates are being considered by many legislators and health officials in other states and nations! These resolutions cannotbe "deferred" until 2009 or swept under the rug to make a few corporations happy, when there is so much at stake in terms of Health and Preventive Medicine.

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Stephen Fox]
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03/04/2008- Excessive intake of aspartame may inhibit the ability of enzymes in the brain to function normally, suggests a new review that could fan the flames of controversy over the sweetener.

The review, by scientists from the University of Pretoria and the University of Limpopo and published recently in the European Journal of Clinical Nutrition, indicated that high consumption of the sweetener may lead to neurodegeneration.

Aspartame is made up of phenylalanine (50 per cent), aspartic acid (40 per cent) and methanol (10 per cent). It is commonly used in food products for the diet or low calorie market, including soft drinks and chewing gums. It was approved for use in foods in the US and EU member states in the early 1980s.

The sweetener has caused much controversy amid suspicions on whether it is entirely safe, with studies linking the ingredient and cancer in rats.

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It has also previously been found that aspartame consumption can cause neurological and behavioural disturbances in sensitive individuals. Symptoms that have been reported include headaches, insomnia and seizures.

Despite strong concerns being raised from some quarters over the sweetener, both the European Food Safety Authority (EFSA) and the US Food and Drug Administration (FDA) have not changed their guidelines regarding the safety of the ingredient or intake advice.

The new review also challenges finding published last year in the journal Critical Reviews in Toxicology (Informa Healthcase) that considered over 500 studies, articles and reports conducted over the last 25 years - including work that was not published, but that was submitted to government bodies as part of the regulatory approvals process.

The earlier review concluded: "The weight of existing evidence s that aspartame is safe at current levels of consumption… No credible evidence was found that aspartame is carcinogenic, neurotoxic, or has any other adverse effect on health when consumed even at quantities many times the established ADI [acceptable daily intake] levels."

New review

Writing in the European Journal of Clinical Nutrition, a Nature journal, the scientists behind the new review state: "The aim of this study was to discuss the direct and indirect cellular effects of aspartame on the brain, and we propose that excessive aspartame ingestion might be involved in the pathogenesis of certain mental disorders, and also in compromised learning and emotional functioning."

The researchers found a number of direct and indirect changes that occur in the brain as a result of high consumption levels of aspartame, leading to neurodegeneration.

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They found aspartame can disturb the metabolism of amino acids, protein structure and metabolism, the integrity of nucleic acids, neuronal function and endocrine balances. It also may change the brain concentrations of catecholamines, which include norepinephrine, epinephrine and domapine.

Additionally, they said the breakdown of aspartame causes nerves to fire excessively, which can indirectly lead to a high rate of neuron depolarisation.

The researchers added: "The energy systems for certain required enzyme reactions become compromised, thus indirectly leading to the inability of enzymes to function optimally.

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