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The Amazing Olive Leaf

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Olive leaf, Olea Europaea
(Image by Wikimedia Commons)
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Olive leaf, Olea Europaea by Wikimedia Commons

The Amazing Olive Leaf

by Jeffrey Dach MD


Link to Original Article

Upper Left Image:  Olive leaf, courtesy of wikimedia commons.

History of the Olive Tree and Leaf

The Fruit and Leaves of the Olive Tree have been used for thousands of years.  Ancient writings contain abundant references to Olive Oil, Olive Trees and the Olive Leaf.  However, the medicinal use of Olive Leaf extract began recently in 1995 with the work of William Frederickson who patented his extraction technique.(37) (Patent )  

Beneficial Properties of Olive Leaf Extract

The Olive Leaf contains beneficial substances which can be extracted and used as a nutritional supplement.  The most abundant phenolic component of the Olive Leaf is called Oleuropein, and this is the major beneficial substance.(9)   Benefits are anti-bacterial, anti-fungal, anti-viral, anti-hypertensive, and anti-diabetic.(9-13)

Nature's Antibiotic- Antibacterial  and Anti Fungal Effects

Morton Walker calls Olive Leaf extract, Nature's Antibiotic , because of its anti-bacterial and anti-fungal properties as demonstrated in many studies (2-6).  Anti-mycoplasma activity was demonstrated in 2004 (1).

For example, Olive Leaf is a useful agent against chronic sinus infection as well as chronic toenail fungus.  Both may harbor underling fungal or bacterial organisms causing the infection. 

Antiviral Activity against influenza

Antiviral activity is another benefit.   For example, Olive leaf extract may be useful in cases of chronic Herpes infection, and Herpes Zoster as well (shingles).( 39)

For those wishing to prevent the common cold, the influenza virus, Olive Leaf extract might prove beneficial because of its anti-viral effect.(7, 16)   Antiviral activity was demonstrated in a 2005 study(7)

Cardiovascular Benefits

Anti-Hypertensive Effects (21-28)

For patients with borderline or mild hypertension, Olive leaf extract has been shown to reduce blood pressure.(21-28)  In one study, Olive leaf extract was compared with the  anti-hypertensive medication Captopril, finding it reduces blood pressure just as well as Captopril, a widely used drug.

Anti-Diabetic (29-30)

For Diabetic patients, Olive leaf has benefits here with reduction in HbgA1c and fasting insulin levels found in a number of studies. (29-30)  Again comparison with anti-diabetic medication showed it was just as good or better than the drug.(29-30)

Anti-lipidemic Effects (34)

For patients concerned about cholesterol and lipids, Olive leaf extract has been found to reduce cholesterol and triglyceride levels, and more importantly prevent LDL oxidation.(34)

Neuroprotective (31)

Olive leaf extract was found to be neuroprotective in an animal model of brain injury.(31)

Conclusion

Abundant published medical studies shows an amazing array of health benefits obtain ed from the humble olive leaf.

Jeffrey Dach MD


Links and References

1) www.ncbi.nlm.nih.gov/pmc/articles/PMC529223/
Antimicrob Agents Chemother. 2004 Dec;48(12):4892-4.
Antimycoplasmal activity of hydroxytyrosol.
Furneri PM, Piperno A, Sajia A, Bisignano G. Department of Microbiological Sciences and Gynecological Sciences, University of Catania, Catania, Italy. Email address removed

2) onlinelibrary.wiley.com/doi/10.1111/j.1574-6968.2001.tb10611.x/full
FEMS Microbiol Lett. 2001 Apr 20;198(1):9-13.
In vitro antibacterial activity of some aliphatic aldehydes from Olea europaea L. Bisignano G, Lagan- MG, Trombetta D, Arena S, Nostro A, Uccella N, Mazzanti G, Saija A. Source Department Farmaco-Biologico, University of Messina, Contrada Annunziata, 98168 Messina, Italy.

3 ) http://www.ncbi.nlm.nih.gov/pubmed/12870202
Mycoses. 2003 Apr;46(3-4):132-6.
In vitro antimicrobial activity of olive leaves.
Markin D, Duek L, Berdicevsky I. Source Department of Microbiology, Rappaport Faculty of Medicine, Technion-Institute of Technology, Haifa, Israel.

4 ) www.pinnaclife.com/sites/default/files/research/Phenolic_Compounds_and_Antimicrobial_Activity_of_Olive_Leaves.pdf
Phenolic compounds and antimicrobial activity of olive (Olea europaea L. Cv. Cobrancosa) leaves.  Authors: Pereira, Ana Paula Ferreira, Isabel C.F.R. Marcelino, F. Valentão, P. Andrade, P.B. Seabra, R.M. Estevinho, Leticia M. Bento, Albino Pereira, J.A. Issue Date: 2007 Publisher: MDPI International Citation: Molecules. ISSN 1420-3049. 12 (2007) p. 1153-1162.

5) www.ncbi.nlm.nih.gov/pubmed/19135874
Int J Antimicrob Agents. 2009 May;33(5):461-3.
Antimicrobial activity of commercial Olea europaea (olive) leaf extract.
Sudjana AN, D'Orazio C, Ryan V, Rasool N, Ng J, Islam N, Riley TV, Hammer KA. Discipline of Microbiology and Immunology, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley, WA 6009, Australia.

6 ) www.ncbi.nlm.nih.gov/pubmed/20106659/
Bioresour Technol. 2010 May;101(10):3751-4.
Antioxidant and antimicrobial activities of individual and combined phenolics in Olea europaea leaf extract. Lee OH, Lee BY. Source Department of Biomedical Science, CHA University, Seongnam 463-836, Republic of Korea.

7) www.pubole.org/bmsite/pages/bm~doc/antiviral-2-2005-olive-leaf-extract-exhibits-antiviral-activity-against-viral-vhsv.pdf
Antiviral Res. 2005 Jun;66(2-3):129-36. Epub 2005 Apr 18.
The olive leaf extract exhibits antiviral activity against viral haemorrhagic septicaemia rhabdovirus (VHSV). Micol V, Caturla N, Pe'rez-Fons L, Ma's V, Pe'rez L, Estepa A. Source Instituto de BiologÃa Molecular y Celular, Universidad Miguel Herna'ndez, E-03202-Elche, Alicante, Spain.

8) www.ncbi.nlm.nih.gov/pmc/articles/PMC3002804/
Sci Pharm. 2010;78(2):133-54.
Oleuropein in olive and its pharmacological effects.
Omar SH.Source College of Pharmacy, Qassim University, P.O. Box-31922, Buraidah-51418, Saudi Arabia. 

9) library.iyte.edu.tr/tezler/master/biyoteknoloji/T000831.pdf
ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES OF OLIVE LEAF EXTRACT AND ITS FOOD APPLICATIONS
Ädegreeszmir Institute of Technology , Ädegreeszmir, Turkey. by Kerem Kaan AYTUL

10) www.ncbi.nlm.nih.gov/pmc/articles/PMC3317714/ (full text) www.ncbi.nlm.nih.gov/pubmed/22489153
Int J Mol Sci. 2012;13(3):3291-340.
Valuable Nutrients and Functional Bioactives in Different Parts of Olive (Olea europaea L.)-A Review. Ghanbari R, Anwar F, Alkharfy KM, Gilani AH, Saari N. Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia;

11) www.thorne.com/altmedrev/.fulltext/14/1/62.pdf
Alternative Medicine Review Volume 14, Number 1 2009
Olive Leaf Introduction - Olive leaf from Olea europaea, the olive tree, is native to the Mediterranean and has been known for its medicinal properties since ancient times.

Morton Walker on Olive Leaf Extract Townsend Letter
12) www.seagateproducts.com/ss-images/townsend-letter-may.pdf
Olive Leaf Extract as a Main Therapy in the Antimicrobial Supermarket
Marton Walker Townsend Letter May 2001

Book by Morton Walker on Amazon
13) Olive Leaf Extract

14)  eastparkresearch.com/studies/antimicrobial-activity-of-d-lenolate/
Antimicrobial Activity of d-Lenolate - east park research olive leaf extract patented extract

15) eastparkresearch.com/studies/therapeutic-effects-of-d-lenolate/
Study: Therapeutic Effect of d-Lenolate - Against Experimental Infections in Immuno-compromised Mice Citation: 2000. Sumiaki Tsuru, Akihito Nagae, Takuya Ohta, Sakae Ohtake, Machio Ibusuki, Masatosi Kaneko. Journal of Orthomolecular Medicine. 15:127-138.

16) orthomolecular.org/library/jom/2001/pdf/2001-v16n02-p102.pdf
(full text) Review of Enhanced Resistance against Influenza Virus by Treatment with Dietary Supplement d-Lenolate  in Neutropenic Mice Induced by Cyclophosphamide. 2001. Sumiaki Tsuru, Machio Ibusuki, Sakae Ohtake, Yoshimi Umezawa, and Masatoshi Kaneko. Journal of Orthomolecular Medicine, 16:102-114.

17) naturamedics.com/booklet/Olive%20leaf%20booklet%20for%20free.pdf
Olive Leaf Extract Potent Antibacterial, Antiviral and Antifungal Agent
Researched by Michele Hansen, N.D. Andrew Verity N.D. Dip H. Dip N. Dip Irid. Copyright 2002 Published in Australia by Goldgolf Pty. Ltd.
18) www.redink-editorial.com/olive_leaf.pdf
Olive leaf extract - nature's antibiotic by Robin JAsko Energy Times )ct 1999

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19) www.manyhands.com/articles/olive.html
The Miracle of the Olive Leaf by Luana Lei

20) georgiaolivegrowers.com/documents/olive_leaf_tea.pdf
Olive Leaf Tea - Mark Hanly MD references
REFERENCES of olive leaf
Aziz, NH, Farag, SE, Mousa, LA, Abo-Zaid, MA.
Comparative antibacterial and antifungal effects of some phenolic compounds. Microbios 1998;93:43-54.

Bisignano, G, Tomaino, A, Lo Cascio, R, Crisafi, G, Uccella, N, Saija, A.
On the in-vitro antimicrobial activity of oleuropein and hydroxytyrosol. J Pharm Pharmacol 1999;51:971-4.

Coni, E, Di Benedetto, R, Di Pasquale, M, Masella, R, Modesti, D, Mattei, R, Carlini, EA. Protective effect of oleuropein, an olive oil biophenol, on low density lipoprotein oxidizability in rabbits. Lipids 2000;35:45-54.

Ficarra, P, Ficarra, R, de Pasquale, A, Monforte, MT, Calabro, ML.
HPLC analysis of oleuropein and some flavonoids in leaf and bud of Olea europaea L. Farmaco 1991;46:803-15.

Saenz, MT, Garcia, MD, Ahumada, MC, Ruiz, V.
Cytostatic activity of some compounds from the unsaponifiable fraction obtained from virgin olive oil.

Farmaco 1998;53:448-9. Tassou, CC, Nychas, GJ, Board, RG.
Effect of phenolic compounds and oleuropein on the germination of Bacillus cereus T spores. Biotechnol Appl Biochem 1991;13:231-7.


Tranter, HS, Tassou, SC, Nychas, GJ.
The effect of the olive phenolic compound, oleuropein, on growth and enterotoxin B production by Staphylococcus aureus.

J Appl Bacteriol 1993;74:253-9. Visioli, F, Bellomo, G, Galli, C.
Free radical-scavenging properties of olive oil polyphenols. Biochem Biophys Res Commun 1998;247:60-4.


HYPERTENSION RX with Olive Leaf extract- reduces BP by 11 mm systolic
21) onlinelibrary.wiley.com/doi/10.1002/ptr.2455/abstract
Phytotherapy Research Volume 22, Issue 9, pages 1239--1242, September 2008
Food supplementation with an olive (Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twins .  Tania Perrinjaquet-Moccetti

22) www.ncbi.nlm.nih.gov/pubmed/21036583
Phytomedicine. 2011 Feb 15;18(4):251-8. doi: 10.1016/j.phymed.2010.08.016. Epub 2010 Oct 30. Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: comparison with Captopril.
Susalit E, Agus N, Effendi I, Tjandrawinata RR, Nofiarny D, Perrinjaquet-Moccetti T, Verbruggen M. Source Nephrology & Hypertension Division, Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr. Cipto Mangunkusumo National General Hospital, Jl. Diponegoro 71, Jakarta 10430, Indonesia.

23) www.lifeextensionretail.com/MagazineArticleDetail.aspx?article=119009
Life Extension Magazine March 2012
Olive Leaf Safely Modulates Blood Pressure By Michael Downey

24) www.ncbi.nlm.nih.gov/pubmed/12489249
Arzneimittelforschung. 2002;52(11):797-802.
Blood pressure lowering effect of an olive leaf extract (Olea europaea) in L-NAME induced hypertension in rats.  Khayyal MT, el-Ghazaly MA, Abdallah DM, Nassar NN, Okpanyi SN, Kreuter MH. Department of Pharmacology, Faculty of Pharmacy, Cairo University, Cairo, Egypt. 

26) www.ncbi.nlm.nih.gov/pubmed/12725563
Phytomedicine. 2003 Mar;10(2-3):115-21.
Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension.  Somova LO, Nadar A, Rammanan P, Shode FO. Source Department of Human Physiology, University of Durban-Westville, Durban, South Africa.

Jonny Bowden olive leaf and hypertension by jonny bowden
27)  jonnybowdenblog.com/olive-leaf-complex-hypertension/

28) www.barleans.com/olive_leaf_book.asp
Unleash the Olive Leaf by Jony Bowden - Barleans olive leaf complex

29) www.ncbi.nlm.nih.gov/pubmed/18844257
Phytother Res. 2009 Mar;23(3):347-50.
Antidiabetic effect of Olea europaea L. in normal and diabetic rats.
Eidi A, Eidi M, Darzi R. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.

30) www.ncbi.nlm.nih.gov/pubmed/22512698
J Med Food. 2012 Jul;15(7):605-10. doi: 10.1089/jmf.2011.0243. Epub 2012 Apr 18.
Olive leaf extract as a hypoglycemic agent in both human diabetic subjects and in rats. Wainstein J, Ganz T, Boaz M, Bar Dayan Y, Dolev E, Kerem Z, Madar Z. Diabetes Unit, E. Wolfson Medical Center, Holon, Israel.

Neuroprotective - olive leaf
31) www.ncbi.nlm.nih.gov/pubmed/21183324
Phytomedicine. 2011 Jan 15;18(2-3):170-5.

32) www.ncbi.nlm.nih.gov/pubmed/22262123
Cytotechnology. 2012 Aug;64(4):459-64. doi: 10.1007/s10616-011-9424-z. Epub 2012 Jan 20. Olive leaf extract modulates permethrin induced genetic and oxidative damage in rats. Turkez H, Togar B, Polat E. Department of Molecular Biology and Genetics, Faculty of Science, Erzurum Technical University, Erzurum, Turkey.

33) www.ncbi.nlm.nih.gov/pubmed/22581435
J Physiol Biochem. 2012 Dec;68(4):583-92. doi: 10.1007/s13105-012-0177-8. Epub 2012 May 13. Oleuropein prevents ethanol-induced gastric ulcers via elevation of antioxidant enzyme activities in rats. Alirezaei M, Dezfoulian O, Neamati S, Rashidipour M, Tanideh N, Kheradmand A. Source Division of Biochemistry, School of Veterinary Medicine, Lorestan University, P.O. Box: 465, Khorram Abad, Iran,

34) www.ncbi.nlm.nih.gov/pubmed/18823963
Chem Biol Interact. 2008 Nov 25;176(2-3):88-98.
Hypolipidimic and antioxidant activities of oleuropein and its hydrolysis derivative-rich extracts from Chemlali olive leaves.
Jemai H, Bouaziz M, Fki I, El Feki A, Sayadi S. Laboratoire des Bioproce'de's, Pôle d'excellence re'gional AUF (PER-LBP), Centre de biotechnologie de Sfax (CBS), BP 1177, 3038 Sfax, Tunisia.

35) upload.wikimedia.org/wikipedia/commons/6/67/Hans_Memling_083.jpg
Angel with an olive branch.[1] Alternative title(s): Angel with an Olive Branch, Emblem of Divine Peace.[2] Date between 1475 and 1480 Medium Oil and gold on panel Dimensions Height: 16 cm (6.3 in). Width: 10 cm (3.9 in). Current location (Inventory)Louvre MuseumLink back to Institution infobox template

36) http://www.ameriden.com/healthspot/the-truth-about-olive-leaf-extract/
The Truth About Olive Leaf Extract
Olive Leaf Extract by Richard L. Hall, 2010

37) Patent by William Frederickson
(US Patent # 6,117,844)

www.google.com/patents?id=3ugKAAAAEBAJ&zoom=4&dq=Antiviral%20Therapy%20with%20Olive%20Leaves.William%20R.%20Fredrickson&pg=PA1#v=onepage&q=Antiviral%20Therapy%20with%20Olive%20Leaves.William%20R.%20Fredrickson&f=false

38) http://www.benolea.com/
 Welcome to the Benolea   website. We are pleased to introduce you to Benolea - (EFLA 943), our patented olive leaf extract. This scientifically proven

39) http://ijms.sums.ac.ir/index.php/ijms/article/viewFile/225/243
The Effect of Hydroalcoholic Extract of Olive Leaves against Herpes Simplex Virus Type 1  M. Motamed  Iran J Med Sci 2007; 32(4): 222-226.

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http://jeffreydachmd.com
Jeffrey Dach MD is a physician and author of two books, Natural Medicine 101, and Bioidentical Hormones 101, both available on Amazon, or as a free e-book on his web sites. Dr. Dach is founder and chief medical officer of TrueMedMD, a clinic in (more...)
 

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