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Life Arts    H4'ed 7/14/10

Marketing Serotonin Deficiency: the Multibillion Dollar Depression Industry

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After 32 years of psychiatric practice I, like many of my colleagues, can't help but be alarmed by the dramatic increase in acute and chronic depression in the last three decades. If anything the incidence of clinical depression and tragically suicide have undergone a dramatic upsurge with the recent economic downturn (and associated unemployment, bankruptcies, foreclosures and homelessness).

The most recent epidemiological data, which predates the October 2008 crash, is as follows:

  • 5.3% of adults are depressed on any given day
  • 12% of women and 7% of men will experience depression in any given year
  • 20% of women will experience depression in their lifetime (the prevalence of depression in men is more difficult to estimate as they are less likely to acknowledge feeling depressed or to seek help).
Given the frequent visits all doctors receive from drug salesman, I am well aware that the pharmaceutical industry has very successfully marketed clinical depression as a "genetic" deficiency of a brain neurotransmitter called serotonin. Which they used to justify a line of enormously profitable drugs called serotonin reuptake inhibitors (SSRIs Prozac is the best known). While antidepressants can be literally life saving for some people, approximately 50% of patients who take them never achieve full recovery. And in the eyes of the medical community, a 50% response rate is a definite embarrassment. This poor response rate is one of the main factors suggesting something other that a genetically inherited "biochemical imbalance" is causing Americans to become depressed.

Animal Models of Depression

The other argument against a strictly biochemical cause of clinical depression is the reality that other mammals including primates don't experience genetically based serotonin deficiency. In order to study the effect of new antidepressants in laboratory animals, depressive disordershave to be artificially created because they don't exist in the wild. Given the high prevalence of depression in human beings, coupled with the fact that the human and chimpanzee DNA is 99% identical, one would expect great apes to show some evidence of genetic, biochemically based depression if this were a genuine medical disorder.

Because depression occurs so rarely in lower mammals, pharmaceutical companies artificially create depressive states in lab animals to test new antidepressants on them. Traditionally researchers employ one of six approaches in making animals depressed all of which induce depression by depleting neurotransmitters (mainly serotonin and norepinephrine):

1. Causing the animal massive, unrelenting stress

2. Imposing social isolation by removing it from other animals

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Dr Stuart Jeanne Bramhall Social Media Pages: Facebook page url on login Profile not filled in       Twitter page url on login Profile not filled in       Linkedin page url on login Profile not filled in       Instagram page url on login Profile not filled in

I am a 63 year old American child and adolescent psychiatrist and political refugee in New Zealand. I have just published a young adult novel THE BATTLE FOR TOMORROW (which won a NABE Pinnacle Achievement Award) about a 16 year old girl who (more...)
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