It seems fitting to conclude on a positive note with these practical, responsible words from Yale epidemiologist Dr. Harvey Risch - words that could well be remembered each day by Dr. Tony Fauci; by the CDC and the FDA; and by any media interested in the public health:
"It is our obligation not to stand by, just 'carefully watching,' as the old and infirm and inner city of us are killed by this disease and our economy is destroyed by it and we have nothing to offer except high-mortality hospital treatment. We have a solution, imperfect, to attempt to deal with the disease. We have to let physicians employing good clinical judgement use it and informed patients choose it. There is a small chance that it may not work. But the urgency demands that we at least start to take that risk and evaluate what happens, and if our situation does not improve we can stop it, but we will know that we did everything that we could instead of sitting by and letting hundreds of thousands die because we did not have the courage to act according to our rational calculations."[xxviii]
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Notes
[i] "SECOND OPINION: Doctors Discuss the Politicization of Hydroxychloroquine," June 18, 2020, at 10:21 min. (https://www.youtube.com/watch?time_continue=7&v=m_JIz780i5w&feature=emb_logo).
[ii] Twitter: https://twitter.com/realDonaldTrump/status/1241367239900778501
[iii] The Lancet, "RETRACTED: Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis, by Mandeep R. Mehra et al," Lancet, 5 June 2010 (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31180-6/fulltext).
[iv] Harvey A. Risch, "Early Outpatient Treatment of Symptomatic, High-Risk Covid-19 Patients that Should be Ramped-Up Immediately as Key to the Pandemic Crisis," Amer. J. Epid, 27 May 2020 (https://academic.oup.com/aje/advance-article/doi/10.1093/aje/kwaa093/5847586). Risch is Professor at the Yale Schools of both Medicine and Public Health.
[v] Elizabeth Woodworth, "The Media Sabotage of Hydroxychloroquine Use for Covid-19: Doctors Worldwide Protest the Disaster," Global Research, 30 June 2020 (https://www.globalresearch.ca/media-sabotage-hydroxychloroquine-covid-19-doctors-worldwide-protest-disaster/5717382).
[vi] X. Yao, F. , et al., "In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),"Clin. Infect. Dis.9 March 2020 (online ahead of print:https://pubmed.ncbi.nlm.nih.gov/32150618/).
Liu, et al., "Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro," Cell Discov, 18 March 2020 p. 16 (https://pubmed.ncbi.nlm.nih.gov/32194981/),
Wang, et al., "Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro," Cell Res, 30, 4 February 2020, pp. 269-271 (https://www.nature.com/articles/s41422-020-0282-0).
[vii] The Chinese studies are cited in this article: P. Gautret P, et al., "Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: a pilot observational study," Travel Medicine and Infectious Disease, March-April 2020 (https://www.sciencedirect.com/science/article/pii/S1477893920301319).
Chen, et al., "Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial," MedRxiv, 10 April 2020, awaiting peer review (https://www.medrxiv.org/content/10.1101/2020.03.22.20040758v3).
[viii] P. Gautret, et al., "Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: a pilot observational study," Travel Medicine and Infectious Disease, March-April 2020 (https://www.sciencedirect.com/science/article/pii/S1477893920301319).
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