With marijuana its largest cash crop, California has the strongest decriminalization movement. At $14 billion annually, cannabis-generated revenue is double that of vegetables and grapes combined.
A decriminalization initiative on the November 2010 ballot was narrowly defeated (53.8% No to 46.2%). A recent analysis in the Nation attributed the defeat to a conspiracy theory circulating among pot growers and elderly users that the tobacco giant R J Reynolds was buying up land and planning a corporate takeover of California production and distribution once personal marijuana use became legal. This was despite an absolute denial by the cigarette manufacturer that have any interest in expanding into marijuana. http://www.thenation.com/article/157001/altered-state-californias-pot-economy
Enter Big Pharma
The rumors have some basis in reality, given the way Big Pharma has moved into the medical marijuana market. In 2007, the British drug company GW Pharmaceuticals announced that it had partnered with the Japanese company Otsuka to bring "Sativex" -- a liquefied marijuana sprayed under the tongue -- to the U.S. Sativex recently completed Phase II efficacy and safety trials studies, and the manufacturer is in discussion with the FDA regarding Phase III testing. Phase III is usually the final step before the drug can be marketed in the US.
Sativex is already in use in Britain, Spain, Germany, Denmark, Canada, the Czech Republic and New Zealand.