Dear Mrs. Martini,
Thank you for contacting the FDA. Your question on 10/6/17 was forwarded to me for a response.
The food additive regulation for Advantame is found under Title 21 of the U.S. Code of Federal Regulations (21 CFR) 172.803 [https://www.ecfr.gov/cgi-bin/retrieveECFR?gp=1&SID=a0505d0802ae61d9d4e60618dd82f43e&ty=HTML&h=L&mc=true&r=SECTION&n=se21.3.172_1803 ].
Additional information on artificial sweeteners can be found at the following links as well:
I hope this answers your question, however please let me know if you require any clarification.
Joseph M. Thomas, Ph.D.
Consumer Safety Officer
Center for Food Safety and Applied Nutrition
Office of Food Additive Safety
U.S. Food and Drug Administration