In 1993, it was discovered that attenuated polio vaccine reverts to its neuro-virulent form with mutations at only two positions. (12)
"Site-directed mutagenesis of P2/Sabin showed that mutations at just two positions, at 481 in the 5" non-coding region and at VP1-143 in the capsid proteins, resulted in a highly neurovirulent virus"(12)
This is the reason why the CDC discontinued use of the live oral vaccine fifteen year ago in the US (in 2000), and switched to the killed inject-able Salk vaccine.
Global Polio Eradication With the Live Oral Vaccine
The experience in India with the live oral polio vaccine is illustrative of the problems encountered with global polio eradication. (5)(36)
Although India was declared "polio-free" with the last case reported January 13, 2011, the numbers of cases of acute flaccid paralysis in children has skyrocketed throughout the campaign.
Here is a quote from Dr. Kaur 2014.(31)
The National Polio Surveillance
Project data show that the polio eradication program has increased
paralysis among children--from 3,047 cases yearly in 1997 to 61,038 cases
in 2012, most now being classified as AFP instead of polio.(31) (note AFP=Acute Flaccid Paralysis)
Here we have "successfully" eradicated wild type polio from a country, India, with the use of oral polio vaccine, yet the number of cases of acute flaccid paralysis has increased 20-fold. This is not success. This is failure. This type of self delusion is typical of government agencies run by morons, however to the most casual observer, this is an obvious farce.
Global Eradication Failure in One Chart -- below
chart courtesy of the World Health Organization showing rise of Acute
Flaccid Paralysis (blue line) while detectable polio virus cases (red
line) decline. The live oral vaccine works quite well at eradicating
detectable wild type polio virus, however the live oral vaccine is a
failure at reducing numbers of children with flaccid paralysis. Click here to see: CHART polio vs AFP Cases in India.
Again, there are many unanswered questions. What is causing these increasing numbers of acute flaccid paralysis in India? Could it be possible that the polio virus is the wrong target, and that acute flaccid paralysis is being caused by some other infectious or non-infectious agent, ? Polio virus is only one of the many enteric viruses which can cause flaccid paralysis. Are there other entero-viruses involved, and which ones?
Neurotoxic Chemicals in Environment?
Are there environmental causes of flaccid paralysis that have been overlooked? Neurotoxic chemicals may cause acute flaccid paralysis. For example, exposure to DDT or other organo-phosphate insecticides can cause neurological disease resembling polio. (2,3) DDT was banned in the US in 1972, yet is still widely used in India. What is the exposure history for these effected children? And what about measuring blood and urine levels of DDT and other toxic chemicals in affected children? None of these studies have been done, so we don't know.
Vitamin C as an Anti-Toxin and Antiviral Agent
It is well known that children with nutritional deficiencies are more susceptible to infection as well as damaging effects of environmental toxins. In view of past research showing success with vitamin C as anti-toxic and anti-viral, wouldn't it be prudent to conduct studies of vitamin C levels on the children with acute flaccid paralysis?(3) Do they have low vitamin C levels? Would vitamin C, in the form of fresh fruits and vegetables, or even supplements, reduce the incidence of acute flaccid paralysis? These are unanswered questions which await further study.
Failure Is Only the Beginning to Find the Real Answers
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