If the SSRIs and opioids simply did not work, it would just be a case of Pharma exploiting unhappiness and raising our health care costs. But both drug classes when used long-term actually make people worse in many cases. Certainly "Prozac poop out" is well known. Less well known is a phenomenon known as "opioid-induced hyperalgesia" or OIH in which opioid use increases pain. It is not much discussed by Pharma.
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