Elife - Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice.
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In mice, the drug rapamycin is known to extend lives and delay some age-related problems. Questions remain about about how it promotes healthy aging, when, how much and how long to administer rapamycin, and how to avoid serious side effects. A new study showed brief therapy during middle age with rapamycin dramatically extended mouse lives. Findings revealed the need to further examine how gender and dose influence side effects and the drug's impact on susceptibility to and protection from different types of cancer.