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Evolution: It's all in how you splice itQuicklink submitted by Kyle McDermott Permalink |
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MIT biologists find that alternative splicing of RNA rewires signaling in different tissues and may often contribute to species differences. When genes were first discovered, the canonical view was that each gene encodes a unique protein. However, biologists later found that segments of genes can be combined in different ways, giving rise to many different proteins. This phenomenon, known as alternative RNA splicing, often alters the outputs of signaling networks in different tissues and may contribute disproportionately to differences between species. Because splicing patterns are more specific to each species, it appears that splicing may contribute preferentially to differences between those species. 'Splicing seems to be more malleable over shorter evolutionary timescales, and may contribute to making species different from one another and helping them adapt in various ways.' |
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