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Gerald Lower

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PdD - McArdle Laboratories for Cancer Research
Gerry Lower, Ph.D. Profile
University of Wisconsin Medical School

Mentor - Prof. Van R.Potter, the Father of "Bioethics" and "Global Bioethics"

Interests: Conceptual Evolution of Natural Science
Conceptual Evolution of Natural Philosophy and the resulting Cultural evolution in
the World. All of Life is Evolutionary.

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Commentary: Reflections on G. M. Lower and colleagues' 1979 study

associating slow acetylator phenotype with urinary bladder cancer:
meta-analysis, historical refinements of the hypothesis, and lessons
learned

Nathaniel Rothman1, Montserrat Garcia-Closas and David W Hein
Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda,
MD20892

"In 1979, Gerald Lower and colleagues published the first epidemiologic
study to directly test the hypothesis that individuals exposed to aromatic
amines would be at higher risk of urinary bladder cancer if they had the
slow acetylator phenotype.1 Not only was the paper a landmark in the
history of bladder cancer carcinogenesis (1), it was one of the very first
efforts to study the effect of a metabolic polymorphism on relative
susceptibility (as opposed to relative risk) for any cancer", one of the
first papers in the area of "Molecular Epidemiology", for which Lower
provided the conceptual foundations (2). Lower has also provided the
conceptual foundations of the Mutagen/Mutation Theory of Neoplastic
Disease (3).

"Lower's work has inspired an entire generation of scientists worldwide
who have studied carcinogenesis, and have sought out a framework to
effectively and thoughtfully integrate the old and new tools of molecular
biology into the broader world of studying and trying to prevent disease."

1) N-acetyltransferase phenotype and risk in urinary bladder cancer:
approaches in molecular epidemiology. Preliminary results in Sweden and
Denmark

Lower GM Jr, Nilsson T, Nelson CE, Wolf H, Gamsky TE, Bryan GT. Environ
Health Perspect. 1979;29:71-9.

2) The Molecular Epidemiology of Arylamine-Induced Urinary Bladder
Cancer: Conceptual foundations
Gerald M.Lower, Jr., Federation Proceedings 42: 129-135,1983.

3) The Mutation Theory of Chronic, Noninfectious Disease: Relevance to
Epidemiologic Theory
Gerald M. Lower, Jr and Marty S.Kanarek, Am J Epidemiology, 115: No. 6,
June, 1982

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9 Articles, 0 Quick Links, 2 Comments, 0 Diaries, 0 Polls

9 Articles

Friday, September 3, 2010
Too Damned Much Money for Anyone
An Institute for POlicy Stodies report shows that "it pays to lay people off."CEOs who laid off the most employees (to further fuel the recession and keep profit margins up) are also the CEOs who took home the largest personal paychecks.

Wednesday, July 14, 2010
OBAMA'S ERODING PUBLIC SUPPORT: Why Do You Suppose That Might Be?
(9 comments) Americans need to pay attention- enraged right wingers are rephrasing the history of the Bush administration & it could cost Obama a second term.

Sunday, December 20, 2009
A "BAH HUMBUG" CHRISTMAS FOR BARACK OBAMA
A Letter to President Obama from two concerned friends pointing out how the President has erred in his handling of the Bush administration and the political right wingr.

Monday, October 19, 2009
THE BRILLIANCE BENEATH OBAMA'S STRATEGY?
(4 comments) This effort is an attempt to make sense out of Obama's adoption of Bush neocon policies and approaches. This may well define the way things will turn out anyway.

Wednesday, October 14, 2009
GOOD MORNING, DEPRESSION - Thank You, Rush Limbaugh
(7 comments) This being my third installment in continuation of the argument that bipolar disorder is a useful metaphor for the comprehension of the current U.S. cultural crisis.

Saturday, October 10, 2009
AMERICAN EXCEPTIONALISM: THE PATH TO CULTURAL BIPOLARISM
This is the second post in which I argue that a useful analogy, an insightful metaphor, for comprehension of our current cultural crisis in the U.S. is found in bipolar disorder (1). As a nation, we are on the verge of going collectively manic, as we did during the GW Bush administration, compliments of Dick Cheney.

Tuesday, October 6, 2009
CONSERVATISM AND CAPITALISM - BRAIN DEAD FOR DECADES
Living in a bipolar nation which says one thing and does the opposite

Saturday, October 3, 2009
ARE WE NOT LAUGHABLE AT BEST?
(2 comments) A discussion of the need to rethink theology in America beginning with the Father of Human Rights and the Father of American Democracy

Thursday, October 1, 2009
Citizen Obama: A Disappointment to the People
(6 comments) Barack Obama assumed that he could implement meaningful change in the U.S. socioeconomic system by accommodating those who brought about the Wars in Iraq and Afghanistan and nourished the global economic meltdown, as opposed to making them accountable. Bad assumption. Having largely failed to make meaningful change in Wall Street, not to mention health care reform, Obama now assumes China and Russia will play ball