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Thiamine, The Paradigm Shift in Diabetes

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Author: Jeffrey Dach MD

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Diabetologia. 2007 October; 50(10): 2164--2170. High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease   P. J. Thornalley,corresponding author1,2 R. Babaei-Jadidi,1 H. Al Ali,1 N. Rabbani,1,2 A. Antonysunil,1,2 J. Larkin,1,2 A. Ahmed,3 G. Rayman,4 and C. W. Bodmer

Orthomolecular Medicine News Service, May 28, 2012
Substituting Vitamins and Supplements for Pharmaceuticals
in Type 2 Diabetes Commentary by Stuart Lindsey, PharmD

(1/B/) // The Vitamin Cure for Diabetes: Prevent and Treat Diabetes Using Nutrition and Vitamin Supplementation Brighthope IE (2012) . Basic Health Publications ISBN-13: 978-1591202905.

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Am J Cardiol. 2007 Jun 18;99(12A):21i-33i. Epub 2007 Apr 16.
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Blood thiamine levels in outpatients with diabetes mellitus.
Saito N, Kimura M, Kuchiba A, Itokawa Y. Source Department of Geriatrics, Kochi Medical University, Japan.

Int J Clin Pract. 2011 Jun;65(6):684-90. Thiamine deficiency in diabetes mellitus and the impact of thiamine replacement on glucose metabolism and vascular disease.Page GL, Laight D, Cummings MH.

3) [PDF]
Effect of Thiamine on Glycemic Control in Diabetic Rats
S Saleem - Ann. Pak. Inst. Med. Sci, 2011 -

Acta Diabetol. 2008 Sep;45(3):131-41. Epub 2008 Jun 26.
Effects of thiamine and benfotiamine on intracellular glucose metabolism and relevance in the prevention of diabetic complications.
Beltramo E, Berrone E, Tarallo S, Porta M. Source
Department of Internal Medicine, University of Turin, Corso AM Dogliotti, 14, 10126, Turin, Italy.

Diabetes Obes Metab. 2011 Jul;13(7):577-83.
Emerging role of thiamine therapy for prevention and treatment of early-stage diabetic nephropathy.  Rabbani N, Thornalley PJ.Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, University Hospital, Coventry, UK.

Diabetologia. 2009 Feb;52(2):208-12. Epub 2008 Dec 5.
High-dose thiamine therapy for patients with type 2 diabetes and microalbuminuria: a randomised, double-blind placebo-controlled pilot study. Rabbani N, Alam SS, Riaz S, Larkin JR, Akhtar MW, Shafi T, Thornalley PJ. Source Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, University Hospital, Clifford Bridge Road, Coventry CV2 2DX, UK.

Diabetes Care. 2010 Jul;33(7):1598-601. Epub 2010 Apr 22.
A double-blind, randomized, placebo-controlled clinical trial on benfotiamine treatment in patients with diabetic nephropathy.  Alkhalaf A, Klooster A, van Oeveren W, Achenbach U, Kleefstra N, Slingerland RJ, Mijnhout GS, Bilo HJ, Gans RO, Navis GJ, Bakker SJ. Source Department of Internal Medicine, University Medical Center Groningen, Groningen, the Netherlands
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Curr Diabetes Rev. 2005 Aug;1(3):287-98.
The potential role of thiamine (vitamin B1) in diabetic complications.
Thornalley PJ. Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, Essex CO4 3SQ, United Kingdom.

8) Diabetes. 2003 Aug;52(8):2110-20.
Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine. Babaei-Jadidi R, Karachalias N, Ahmed N, Battah S, Thornalley PJ. Source epartment of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, Essex, UK.

J Clin Med Res. 2012 June; 4(3): 153--160.
The Impact of Thiamine Treatment in the Diabetes Mellitus
Khanh vinh quoc Luonga,b and Lan Thi Hoang Nguyena

International Journal of Clinical Practice
Volume 65, Issue 6, pages 684--690, June 2011 REVIEW ARTICLE
Thiamine deficiency in diabetes mellitus and the impact of thiamine replacement on glucose metabolism and vascular disease
G. L. J. Page1, D. Laight2, M. H. Cummings1
Article first published online: 12 MAY 2011

Rapid HPLC measurement of thiamine and its phosphate esters in whole blood. Lu J, Frank EL. Clin Chem 2008; 54: 901--6.

Diabetologia. 2004 Dec;47(12):2235-46. Epub 2004 Dec 11.
High-dose thiamine therapy counters dyslipidaemia in streptozotocin-induced diabetic rats. by Babaei-Jadidi R, Karachalias N, Kupich C, Ahmed N, Thornalley PJ. Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex, CO4 3SQ, UK.

Ann N Y Acad Sci. 2005 Jun;1043:777-83.
High-dose thiamine therapy counters dyslipidemia and advanced glycation of plasma protein in streptozotocin-induced diabetic rats. Karachalias N, Babaei-Jadidi R, Kupich C, Ahmed N, Thornalley PJ. Source Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK.

J Toxicol Sci. 2008 Oct;33(4):459-72.
Prevention of incipient diabetic cardiomyopathy by high-dose thiamine.
Kohda Y, Shirakawa H, Yamane K, Otsuka K, Kono T, Terasaki F, Tanaka T. Source Laboratory of Pharmacotherapy, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan.

Diabetologia. 2006 Feb;49(2):405-20. Epub 2006 Jan 17.
Benfotiamine accelerates the healing of ischaemic diabetic limbs in mice through protein kinase B/Akt-mediated potentiation of angiogenesis and inhibition of apoptosis. Gadau S, Emanueli C, Van Linthout S, Graiani G, Todaro M, Meloni M, Campesi I, Invernici G, Spillmann F, Ward K, Madeddu P. Source Experimental Medicine and Gene Therapy, National Institute of Biostructures and Biosystems (INB, Osilo, Italy. Benfotiamine, a vitamin B1 analogue, reportedly prevents diabetic microangiopathy.

Nat Med. 2003 Mar;9(3):294-9. Epub 2003 Feb 18.
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Hammes HP, Du X, Edelstein D, Taguchi T, Matsumura T, Ju Q, Lin J, Bierhaus A, Nawroth P, Hannak D, Neumaier M, Bergfeld R, Giardino I, Brownlee M. Source Medical Clinic V, School of Clinical Medicine, Mannheim, Germany.

Exp Clin Endocrinol Diabetes. 2008 Nov;116(10):600-5. Epub 2008 May 13. Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study.
Stracke H, Gaus W, Achenbach U, Federlin K, Bretzel RG. Medical Clinic und Policlinic III, University Hospital Giessen and Marburg, Location Giessen, Germany.

This site was established to provide visitors with comprehensive information about benfotiamine, a synthetic derivative of thiamine (vitamin B-1) which shows promise in treating a number of neurological and vascular conditions.

Pharmacol Res. 2010 Jun;61(6):482-8. Epub 2010 Feb 25.
The multifaceted therapeutic potential of benfotiamine.
Balakumar P, Rohilla A, Krishan P, Solairaj P, Thangathirupathi A. Source Department of Pharmacology, SB College of Pharmacy, Sivakasi 626130, India.

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Jeffrey Dach MD is a physician and author of two books, Natural Medicine 101, and Bioidentical Hormones 101, both available on Amazon, or as a free e-book on his web sites. Dr. Dach is founder and chief medical officer of TrueMedMD, a clinic in (more...)

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