Neurological/
Cognitive yes yes
Gastrointestinal yes yes
Figure 1, (1,3,4)
Does a common denominator of AChEi exposure explain such mirror imagery?
Again,
potent AChEis emanate from particular groups of fungi often associated
with incidents of SBS, or more specifically, from particular mycotoxins
within these groups.(5,6,7) However, to date and in contrast to GWI, it
appears research has yet to address the potential health effects this
AChEi exposure may generate or the explanation for SBS it may provide.
We
believe the SBS question may well be associated with mycotoxins such as
Territrem B (TRB), "a potent and irreversible inhibitor of
acetylcholinesterase (AChE)",(5) and one which has been found to exist
in both Penicillium sp FO-4259 (6) and Aspergillus terreus.(5) This is
particularly significant given that both Penicillium and Aspergillus are
commonly associated with SBS,(7) though questions remain as to how
broadly AChEis generally, and mycotoxins such as TRB particularly, may
be found within each genus, as well as within other indoor molds.
AChEi Strength
IC50 (uM)
Arisugacin A
1.0
Territrem C
6.8
Territrem B
7.6
Arisugacin B
25.8
Low-Level Exposure and Chronic Symptoms
Questions
regarding the impact of repeated low-level exposures to potentially
toxic agents exist within the circumstances of both GWI and SBS. For
GWI, "evidence of chronic and delayed consequences to physiological
systems from repeated low-level AChEi exposure" was found, with it being
added that "evidence for persistent and delayed effects of low-level
exposure is accruing".(1)
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