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3
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made illegal in Britain.
1927 Canada bans all forms of cannabis.
1937 Even though there are 28 cannabis pharmaceuticals on the American
market, Cannabis banned in US with federal law, the 1937 Marijuana Tax Act.
1964 THC, tetra hydro cannabinol, the psycho-active component of cannabis,
isolated by Raphael Mechoulam at Weizmann Institute in Israel.
1970 Marijuana fully outlawed in US by Controlled Substances Act of 1970.
1975 Munson shows anti cancer effects of cannabis in Lewis Lung Tumors.
1980-2000 Cannabis research banned in US (de facto).
1985 FDA approves Marinol drug, a pure THC drug.
1992 First endo-cannabinoid isolated by Hanuš, Devane in Raphael Mechoulam's lab at the Hebrew University in Jerusalem. This new substance is named Anandamide.
1990 endo-cannabinoid CB1 receptors cloned and found in brain.
1993 endo-cannabinoid CB2 receptors cloned and found in the immune system.
1998 Di Marzo's in Naples Italy group found that cannabinoids (anandamide) inhibit breast cancer cell proliferation.
1999, Marinol (THC) was rescheduled from Schedule II to III of the Controlled Substances Act,
2000 Guzman's group in Spain found that cannabinoids inhibit the growth of C6 glioma cells.
2005 Sativex approved in Canada. Sativex is a whole cannabis plant extract, mouth spray approved for multiple sclerosis patients to alleviate neuropathic pain and muscle spasticity.
2006 Cannabindiol found useful as anti-psychotic drug São Paulo, Brasil.
