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Worse, like hormone therapy itself, scientists increasingly believe bisphosphonates can actually cause the fractures they were designed to prevent because the non-renewed bone becomes brittle. Atypical skeletal fragility, subtrochanteric stress fractures and delayed healing of fractures are frequently seen.
And then there's cancer.
Twenty-three cases of esophageal cancer in bisphosphonate patients in the US since 1995 were reported earlier this year in the New England Journal of Medicine. Eight were fatal. In Europe and Japan, 31 cases were reported, six of them fatal.
Clearly, like the Old Woman, each new therapy is worse than the one before--and no one remembers why she even swallowed the fly.
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